Introduction/Background Adenoid cystic carcinoma (ACC) of the breast is a rare tumor, accounting for only 0.1% of all malignant breast tumors. The clinical signs are not very specific as are the radiological aspects often showing criteria of benignity.

Methodology We report two cases of breast ACC treated in our radiotherapy oncology department in Sousse in 2012 and 2016.

Results Case 1: Ms. XY, aged 60, who consulted for mastodynia on the left. The appearance on echo mammography was in favor of a macro lobulated oval mass with low vascularization on Doppler, measuring 25*19mm (ACR4). Biopsy confirmed a breast ACC with a triple negative profile. The patient underwent a lumpectomy with an axillary dissection. The biopsy showed a tumor of 2.2 cm, SBR II. She had radiotherapy of the left breast at a dose of 52.2 Gy and a boost on the tumor bed at a dose of 14.4 Gy. The patient has since been lost to follow-up.

Case 2: Ms. AL, aged 64, having presented with right mastodynia. On clinical examination, it was a 3 cm nodule in the right breast. The echo mammogram showed a mass with irregular contours in the upper outer quadrant of the right breast classified ACR4. On biopsy, it was a ACC of the breast, triple negative with a proliferation index ki 67 <1%. She had a lumpectomy with surgical margins returning positive followed by a complement mastectomy. at histology, there was a residue of an infiltrating ductal carcinoma measuring 1 cm, SBR II, in contact with the lumpectomy cavity. she had adjuvant chemotherapy followed by chest wall radiotherapy at dose of 52.2. The patient was in complete remission for 3 years.bio.

Conclusion Treatment of ACC of the breast is not well established. Compared to other locations, adenoid cystic carcinoma of the breast has a favorable prognosis.

Disclosures NO.