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1337 CA125 to PCI ratio: could it define different groups of disease?
  1. Olena Postupalenko and
  2. Kateryna Kharchenko
  1. Kyiv City Clinical Oncology Center, Kyiv, Ukraine


Introduction/Background Theoretically, the ability of each carcinomatosis ‘unit’ to produce CA125 could be potential marker for disease peculiarities.

Methodology Retrospective exploratory analysis of operative reports of ovarian cancer patients who received cytoreductive surgery from 2020 to 2023 years in department of minimally invasive surgery (Kyiv City Clinical Oncology Center). IBM SPSS Statistics 23 was used.

Results One hundred six cases were identified. They were empirically divided into two groups: group 1 (n=71) - CA125 to PCI ratio was 0–14, group 2 (n=35) - CA125 to PCI ratio was 15 and more. Interestingly, that mean PCI was the same for both groups – 14. As well the same were duration of surgery (423 min). Almost the same was blood loss, 375 in group 1 and 407 in group 2. In contrast, mean CA125 was 85 and 1165 respectively. The majority of group 2 were patients who received primary debulking surgery (n=22, 63%). The same kind of surgery represent 25% (n=18) in group 1. The opposite trend was toward interval debulking: 33 cases (47%) in group 1 and 8 (23%) in group 2. Recurrent represent 17 cases (24%) and 4 cases (11%) respectively, redebulking – 3 (4%) and 1 (3%) respectively. The most interesting difference was in lymph node status. Lymph node removal was performed in 36 cases (51%) of group 1 and 28 cases (80%) of group 2. Metastases were approved in 19 (53%) and 18 (64%) cases respectively. So, the incidence of lymph node metastases was 27% in group 1 and 51% in group 2.

Conclusion CA125 to PCI ratio could potentially predict lymph node status. Further research needed to determine the potential predictive and prognostic benefit of CA125 to PCI ratio.

Disclosures None.

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