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1279 A rare case of ovarian cancer with metastasis in the uterine cervix
  1. Viktorija Jovanovska,
  2. Marjan Stojovski,
  3. Daniel Milkovski,
  4. Vlatko Gjirevski and
  5. Ivana Kijajova
  1. University Clinic of Gynecology and Obstetrics, Skopje, North Macedonia


Introduction/Background Ovarian carcinoma is the seventh most common cancer in women worldwide. Most often, patients with ovarian cancer are diagnosed in the advanced stage of the disease. Ovarian carcinoma mainly metastasizes via intraperitoneal and lymphatic routes, and blood-borne metastases rarely occur. The most common metastatic sites are the peritoneum, liver and lymph nodes. Metastases of ovarian cancer in the cervix are rarely seen. The average survival of these patients in the literature is 4.4 months.

Methodology Case report.

Results A 54-year-old female patient presented with a sudden onset of abdominal discomfort. Gynaecological examination, ultrasound and CT confirmed a right-sided cystic solid tumour of the ovary with ascites, pleural effusion, enlarged lymph glands and a dilated, irregular cervix of the uterus. Laboratory results showed increased value for the tumor marker Ca125 >500 U/ml. A biopsy of the cervix was performed and a histological diagnosis of serous ovarian carcinoma was obtained as a metastasis to the cervix of the uterus. The patient underwent a complete oncological treatment with chemotherapy and radiotherapy. One year after completing the therapy, due to the size of the adnexal tumors, the patient underwent palliative surgical treatment with bilateral adnexectomy, since a complete surgical oncological treatment was not possible. Histopathological findings were consistent with ovarian serous adenocarcinoma. The patient was later referred again for chemotherapy treatment. The patient died about two years after receiving the diagnosis and starting the oncological treatment.

Conclusion Metastasis of ovarian cancer to the female genital tract is a rare entity. Half of the secondary tumors of the female genital tract are of gastrointestinal origin. As cervical metastases are rare, such lesions can be insidious and mimic a primary disease.

Disclosures No conflicts of interest are reported.

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