Introduction/Background Brenner’s tumor is a rare disease affecting the female reproductive organs, particularly the ovaries, and is generally benign.

It is a small, solid, benign tumor located on the ovaries.

Methodology We carried out a retrospective study of 02 cases of Brenner’s tumours.

These tumors were collected in the gynecology department at the gynecology and obstetrics I department of the Hassan II University Hospital in Fez over a 7-year period, between November 2017 and November 2023 .

Results Histologically, Brenner’s tumors appear as well-differentiated, non-infiltrative excreto-urinary carcinomas.

We report two young patients who underwent surgery for ovarian tumors.

We describe in detail the anatomical and clinical features of this rare entity, which poses problems of positive diagnosis, differential diagnosis and management.

Conclusion Brenner’s tumours represent only 1–2% of all ovarian tumours, and their symptomatology and biological and radiological signs are not very specific.

The differential diagnosis of Brenner tumors at the limit of malignancy leads to discussion of transitional or secondary carcinomas.

Brenner tumors are almost always benign, making the diagnosis, prognosis and treatment of benign Brenner tumors well codified.

Disclosures Only 10% of benign Bernner tumors are symptomatic: abdomino-pelvic pain; sometimes endocrine clinical signs related to estrogen secretion (endometrial thickening and metrorrhagia) or androgen secretion by the stromal component of the tumor.

Immunohistochemistry Transitional-type cells are: CK7, EMA, p63, uroplakin-III (UP3), thromomodulin (TBM): positive immunostains.

Chromogranin, serotonin, WT1 (Mullerian profile): sometimes focally positive.

CK20 negative, but sometimes positive focal immunostaining at the apical pole of cells bordering microcysts.

Inhibin negative, but positive in the case of stromal luteinization.