Introduction/Background Prophylactic salpingectomy (PS) for the prevention of ovarian cancer is evidence-based, recommended and established at the time of gynecologic surgery. Nongynecologic procedures such as cholecystectomy would be further potential opportunities to offer PS.

Methodology We developed a simulation model to estimate the potential effects of PS at planned cholecystectomy and other nongynecologic surgical procedures in future. The model was created for the Austrian region of Styria, which currently has a population including about 633,000 women and about 110 new cases of ovarian cancers per year. The simulation covers a time span of 100 future years.

Results Different scenarios were defined with different data and assumptions, such as how many women would agree to PS and how much effect is assumed. The best-case scenario for cholecystectomy, assuming that all women ≥40 years undergoing cholecystectomy would agree to PS, shows a reduction of about 6.39 cases (4.75%) per year in Styria, compared to the base scenario, where no PS is applied.

Conclusion Simulation results indicate that expanding PS to nongynecologic procedure could reduce the incidence of ovarian cancer. As the model has several simplifications, we are planning further simulation scenarios as well as model adjustments to get closer to reality. Another further step will be expanding the model to nongynecologic procedures beyond cholecystectomy.

Disclosures No disclosures.