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635 Survival rate differences in patients with interval cytoreductive surgery with serous ovarian cancer between those who have supradiaphragmatic disease and those who not
  1. Teresa Micaela Arrufat,
  2. Mar Bort,
  3. Maria Teresa Climent,
  4. Anna Serra and
  5. Jose Antonio Llueca
  1. General University Hospital of Castellón., Castellón De La Plana, Spain


Introduction/Background The objective of this study is to investigate the impact of supradiaphragmatic disease (SD) on the survival outcomes and disease-free interval in patients with SOC undergoing interval debulking surgery after NACT. The investigation is conducted in collaboration with the reference unit of abdomino-pelvic surgery (URCOAP) at the General University Hospital of Castellón.

Methodology A retrospective cohort study including 38 cases from 2006 to 2022 will be conducted, involving patients diagnosed with SOC who underwent NACT followed by interval cytoreductive surgery.

Results In our study, we identified 38 patients meeting the specified criteria, with an average age of 60 years. Among this cohort, 23% were in stage IIIC, 2% in stage IVA, and 12% in stage IVB according to the FIGO classification. Of these patients, 33 patients had no evidence of SD, while 5 were diagnosed with SD through preoperative CT scans. We observed a median survival estimate of 53 months (95% CI 31.0–74.5) in patients without SD and 24 months (95% CI 8.5–39.2) in those with SD. Regarding the disease-free interval, a median of 10 months (95% CI 8–13) and 5 months (95% CI 2–23) was observed, respectively. Notably, among the 5 patients with SD, intraoperative thoracoscopy was performed in 4, confirming the presence of SD in 3 of them.

Conclusion In conclusion, our study suggests that the presence of SD affects negatively on both overall survival and disease-free interval in advanced-stage SOC patients undergoing interval cytoreductive surgery who underwent NACT.

Disclosures The authors report no conflicts of interest in this work.

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