Introduction/Background Ovarian cancer is the eighth leading cause of most cancer-related deaths in women worldwide and rank third in mortality, after cervical and uterine cancer. This study was conducted to report the profile of ovarian cancer in Indonesia from 2010 to 2020 based on records from Indonesian Society of Gynecologic Oncology (INASGO) Cancer Registry.

Methodology A retrospective study was conducted by recruiting all confirms cancer patients registered at the Cancer Registry, based on data from the INASGO Cancer Registry from 2010 to 2020

Results Based on the INASGO cancer registry, the prevalence of ovarian cancer ranks second in cases of gynecological cancer after cervical cancer, which is 790 compared to 4420 cases. According to histotype classification, epithelial ovarian cancer (EOC) is still dominant (84%) like in the global situation (90%), yet the subhistotypes are significantly different. In global, serous type is the dominant subhistotype (75%) followed by clear cell and endometrioid type with 10% each, and mucinous type 5%. While serous type in Indonesia is just less than a half from the global data. Mucinous and clear cell type in Indonesia is more than twice compared to global. In general, EOC subhistotype in Indonesia is comparable, which serous, mucinous, clear cell, and endometrioid type were 36%, 23%, 22% and 19%, consecutively. The most significant risk factor was nulliparity.

Conclusion From this study during 2010–2020, the most common type of ovarian cancer in Indonesia is EOC. There was a significant difference in the epithelial subtype in Indonesia compared to the global which was influenced by parity status.

Disclosures Nothing to disclose.

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Abstract 560 Figure 1