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494 Prognostic role of C reactive protein to albumin ratio in advanced stage ovarian cancer patients
  1. Nicolae Bacalbasa1,
  2. Irina Balescu2,
  3. Mihai Eftimie1,
  4. Sorin Petrea3,
  5. Lucian Pop4,
  6. Bogdan Gaspar5,
  7. Valentin Varlas6,
  8. Adrian Hasegan7,
  9. Cristina Martac8,
  10. Ciprian Bolca9,
  11. Marilena Stoian10,
  12. Cezar Stroescu8 and
  13. Simona Dima8
  1. 1Fundeni Clinical Institute, Bucuresti, Romania
  2. 2Carol Davila University of Medicine and Pharmacy, Bucuresti, Romania
  3. 3Ion Cantacuzino Clinical Hospital, Bucuresti, Romania
  4. 4National Institute of Mother and Child Care Alessandrescu-Rusescu, Bucuresti, Romania
  5. 5Floreasca Clinical Emergency Hospital, Bucuresti, Romania
  6. 6Filantropia Clinical Hospital, Bucuresti, Romania
  7. 7Sibiu Clinical Hospital, Sibu, Romania
  8. 8Fundeni Clinical Institute, Bucharest, Romania
  9. 9Charles LeMoyne Hospital, Longueuil, Canada
  10. 10Ion Cantacuzino Clinical Hospital, Bucharest, Romania


Introduction/Background Both nutritional and inflammatory status seem to play a central role in the evolution of ovarian cancer patients. The aim of the current paper is to investigate the association between C reactive protein to albumin ratio and the postoperative outcomes of ovarian cancer patients.

Methodology In the current paper we introduced 107 patients diagnosed with epithelial ovarian cancer submitted to per primam debulking surgery. An optimal cutoff value of 0,75 was obtained using the receiver operation curve

Results Higher levels of this parameter were significantly associated with higher values of CA125 (p=0,02), higher stages (p=0,04), incomplete debulking (p=0,02) and with more frequent postoperative complications (p=0,004). When it comes to the long term outcomes, higher values of CRP/albumin ratio were associated with significantly poorer disease free and overall survival (12,3 and 18 months respectively) when compared to cases with lower values of this parameter (15,1 months and 26 months respectively) (p=0,001 and p=0,0004 respectively).

Conclusion CRP/albumin ratio represents a significant prognostic marker which seems to identify cases at risk to have a poorer evolution after per primamdebulking surgery. Therefore such cases might benefit more if neoadjuvant chemotherapy is administrated.

Disclosures None.

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