Article Text

Download PDFPDF
489 Lymphocyte to monocyte ratio as a prognostic factor in ovarian cancer
  1. Nicolae Bacalbasa1,
  2. Irina Balescu2,
  3. Mihai Eftimie1,
  4. Sorin Petrea3,
  5. Bogdan Gaspar4,
  6. Lucian Pop5,
  7. Valentin Varlas6,
  8. Adrian Hasegan7,
  9. Cristina Martac8,
  10. Ciprian Bolca9,
  11. Marilena Stoian10,
  12. Cezar Stroescu8 and
  13. Simona Dima8
  1. 1Fundeni Clinical Institute, Bucuresti, Romania
  2. 2Carol Davila University of Medicine and Pharmacy, Bucuresti, Romania
  3. 3Ion Cantacuzino Clinical Hospital, Bucuresti, Romania
  4. 4Floreasca Clinical Emergency Hospital, Bucuresti, Romania
  5. 5National Institute of Mother and Child Care Alessandrescu-Rusescu, Bucuresti, Romania
  6. 6Filantropia Clinical Hospital, Bucuresti, Romania
  7. 7Sibiu Clinical Hospital, Sibiu, Romania
  8. 8Fundeni Clinical Institute, Bucharest, Romania
  9. 9Charles LeMoyne Hospital, Longueuil, Canada
  10. 10Ion Cantacuzino Clinical Hospital, Bucharest, Romania


Introduction/Background The presence of a lower preoperative level of lymphocytes is usually associated with poor outcomes in advanced stage ovarian cancer, revealing a poor response of the immune system to tumoral cells. The aim of the current paper is to investigate the correlation between preoperative lymphocyte to monocyte ratio and the perioperative outcomes of patients with epithelial ovarian cancer.

Methodology Between 2014–2020 there were 107 cases of patients diagnosed with advanced stage epithelial ovarian cancer who were submitted to debulking surgery with curative intent.

Results Mean preoperative level of lymphocyte to monocyte ratio (LMR) was 3,12 (range 0,7 -6,7) and was significantly correlated with more advanced stages of the disease (p=0,023), with the presence of lymph node metastases (p=0,038), with higher levels of CA125 (p=0,04) and with a poorer disease free and respectively overall survival (p=0,01 and respectively p<0,01). However, a statistically significant correlation failed to be observed between LMR and age (p=0,44), the presence of preoperative comorbidities (p=0,71) and the differentiation degree (p=0,91).

Conclusion LMR seems to be a promising marker in order to identify cases with a poorer biology of the tumor in which a more aggressive systemic therapy could be necessary in order to improve the long term outcomes.

Disclosures None.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.