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488 Hemoglobin levels correlate with systemic inflammatory index in advanced stage ovarian cancer
  1. Nicolae Bacalbasa1,
  2. Irina Balescu2,
  3. Mihai Eftimie1,
  4. Sorin Petrea3,
  5. Bogdan Gaspar4,
  6. Lucian Pop5,
  7. Valentin Varlas6,
  8. Adrian Hasegan7,
  9. Cristina Martac8,
  10. Ciprian Bolca9,
  11. Marilena Stoian10,
  12. Cezar Stroescu8 and
  13. Simona Dima8
  1. 1Fundeni Clinical Institute, Bucuresti, Romania
  2. 2Carol Davila University of Medicine and Pharmacy, Bucuresti, Romania
  3. 3Ion Cantacuzino Clinical Hospital, Bucuresti, Romania
  4. 4Floreasca Clinical Emergency Hospital, Bucuresti, Romania
  5. 5National Institute of Mother and Child Care Alessandrescu-Rusescu, Bucuresti, Romania
  6. 6Filantropia Clinical Hospital, Bucuresti, Romania
  7. 7Sibiu Clinical Hospital, Sibiu, Romania
  8. 8Fundeni Clinical Institute, Bucharest, Romania
  9. 9‘Charles LeMoyne’, Longueuil, Canada
  10. 10Ion Cantacuzino Clinical Hospital, Bucharest, Romania


Introduction/Background Anemia represents a common finding among neoplastic patients and is caused by multiple mechanisms including due to the inflammatory status induced by the presence of malignant cells. The aim of the current paper is to investigate the correlation between these two entities among cases diagnosed with advanced stage ovarian ca

Methodology Preoperative data of patients submitted to debulking surgery between 2014–2020 in Ion Cantacuzino hospital were retrospectively reviewed.

Results A total number of 57 patients were considered as eligible for this study: By using the receiver operation curve (ROC) a cut off value of 841000 was obtained with an area under the ROC curve (AUC) of 0,787 (sensibility=0,83, 1- specificity=0,29). According to this value the study group was divided in two subgroups: the first one included patients with SII < 841.000 – 20 cases while the second one included patients with SII >841.000 - 37 cases. When it comes to the preoperative level of hemoglobin, a mean value of 12,2 g/dl was obtained, this value being significantly lower among patients with higher levels of SII (11,4g/dl) versus those with lower SII levels (and in which the mean preoperative value of hemoglobin was of 13,1 g/dl) (p=0,005). Moreover, when analyzing the preoperative data, there were 41 cases in FIGO stage IIIC and respectively 16 cases diagnosed in FIGO stage IV. Patients diagnosed with FIGO stage IIIC of disease had a mean value of SII of 789001 while cases diagnosed in FIGO stage IV of disease had a mean SII value of 1890256 (p=0,003) and respectively a mean value of hemoglobin of 12,8 g/dl versus 10,8 g/dl (p=0,002).

Conclusion Preoperative levels of hemoglobin seem to be significantly correlated with preoperative SII values; meanwhile both values seem to be significantly corelated with FIGO stage in advanced stage ovarian cancer.

Disclosures None.

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