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487 Is there a correlation between systemic inflammatory index and extent of peritoneal carcinomatosis in advanced stage ovarian cancer?
  1. Irina Balescu1,
  2. Mihai Eftimie2,
  3. Sorin Petrea3,
  4. Bogdan Gaspar4,
  5. Lucian Pop5,
  6. Valentin Varlas6,
  7. Adrian Hasegan7,
  8. Cristina Martac8,
  9. Ciprian Bolca9,
  10. Marilena Stoian10,
  11. Cezar Stroescu11,
  12. Simona Dima8 and
  13. Nicolae Bacalbasa8
  1. 1Carol Davila University, Bucuresti, Romania
  2. 2Fundeni Clinical Institute, Bucuresti, Romania
  3. 3Ion Cantacuzino Clinical Hospital, Bucuresti, Romania
  4. 4Floreasca emergency Clinical Hospital, Bucuresti, Romania
  5. 5National Institute of Mother and Child Care Alessandrescu-Rusescu, Bucuresti, Romania
  6. 6Filantropia Clinical Hospital, Bucuresti, Romania
  7. 7Sibiu Clinical Hospital, Sibiu, Romania
  8. 8Fundeni Clinical Institute, Bucharest, Romania
  9. 9Charles LeMoyne’ Hospital, Longueuil, Canada
  10. 10, Bucharest, Romania
  11. 11Ion Cantacuzino Clinical Hospital, Bucharest, Romania

Abstract

Introduction/Background The extent of peritoneal carcinomatosis represents the most frequently encountered reason for incomplete debulking in advanced stage ovarian cancer. Therefore, attention was focused on identifying a prognostic marker which might provide a better identification of these cases preoperatively. Systemic inflammatory index, defined as the platelets*neutrophils/lymphocytes seems to provide significant information regarding the extent of the disease.

Methodology Between 2014–2020 57 patients diagnosed with peritoneal carcinomatosis from ovarian cancer were submitted to surgery in Ion Cantacuzino hospital. Patients were further classified in three groups according to the extent of peritoneal carcinomatosis (defined by the peritoneal carcinomatosis index – PCI): PCI<10 – 14 cases, PCI between 10–15 – 21 cases and PCI>15 - 12 cases.

Results Preoperative values of SII ranged between 871674 and 7458168, with a mean value of 2424479. Meanwhile, we determined the intraoperative volume of ascites, a mean value of 2350 ml being obtained (range 300–8000ml). Cases in the first group reported a mean SII level of 761786, those in the second group reported a mean SII level of 1276485 while those in the third group reported a mean SII level of 68760393 (p<0,0001). Meanwhile a positive correlation was established between the ascites volume and the preoperative level of SII (p=0,001). When analyzing the completeness of cytoreduction, maximal debulking was achieved in 46 out of the 57 cases; cases in which maximal debulking was feasible had a mean value of SII of 1175802 while cases in which debulking was incomplete had a preoperative value of SII of 4190031 (p<0,0001).

Conclusion Preoperative SII seems to have a prognostic value in order to identify cases in which maximal debulking surgery is not feasible; therefore, such cases should be rather submitted to neoadjuvant chemotherapy followed by interval debulking surgery than to per primam attempt of debulking.

Disclosures None.

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