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284 Is cardiopulmonary exercise testing predictive of surgical complications in patients undergoing surgery for ovarian cancer?
  1. Anke Smits1,
  2. Claire-Marie Agius2,
  3. Dominic Blake2,
  4. Christine Ang2,
  5. Ali Kucukmetin2,
  6. Maaike Van Ham1,
  7. Johanna Pijnenborg1,
  8. Joanne Knight3 and
  9. Stuart Rundle3
  1. 1Radboudumc, Nijmegen, The Netherlands
  2. 2Queen Elizabeth Hospital, Gateshead, UK
  3. 3Queen Elizabeth Hospital, Gateshead, The Netherlands


Introduction/Background Preoperative cardiopulmonary exercise testing (CPET) provides an objective assessment of functional capability. In other intra-abdominal surgical specialties, CPET outcomes are predictive of operative morbidity. However, in ovarian cancer surgery, its predictive value remains unknown. In this study, we evaluated the association between CPET performance and surgical morbidity in ovarian cancer patients. Secondly, we assessed the association between CPET performance and other surgical outcomes (i.e., hospital stay, readmission and residual disease).

Methodology This was a retrospective cohort study of patients undergoing primary surgery for ovarian cancer between 2020 and 2023. CPET performance included peak oxygen uptake (VO2 max), ventilatory efficiency (VE/VO2) and anaerobic threshold. Outcomes were operative morbidity and included intra- and postoperative complications (Clavien-Dindo), hospital stay, readmission within 30 days and residual disease.

Results A total of 142 patients were included. A lower VO2 peak and a higher VE/VCO2 were both associated with the occurrence of postoperative complications, and a poorer anaerobic threshold was associated with more transfusions. VE/VCO2 remained significantly associated after multivariate analysis (p = 0.035). None of the CPET outcomes were associated with length of stay, readmission or residual disease.

Conclusion In conclusion, VE/VCO2 was significantly associated with an increased risk of all-cause postoperative complications in ovarian cancer patients undergoing primary surgery.

Disclosures None.

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