Introduction/Background Preoperative evaluation of myometrial invasion in endometrial cancer (EC) is important for surgical planning. Our study aimed to evaluate and compare the diagnostic accuracy (DTA) of 3D-transvaginal ultrasound (3D-TVS) and magnetic resonance imaging (MRI) for detecting deep myometrial infiltration (DMI) for preoperative staging and surgery planning in patients with EC.

Methodology In this prospective double-blind study, a patients diagnosed with endometrial cancer at the Gynaecologic Oncology University Hospital of Padua were included. We collected data about patient’s general features and clinical data (Histology and grade). The diagnostic sensitivity (SE), specificity (SP), and DTA in detecting DMI were evaluated by 3D-TVS and MRI and compared with the final histology as a gold standard.

Results We present the preliminary results about 38 patients. Mean BMI was 29.51 kg/m2 ± 7.49, mean age at the moment of the surgery was 65.02 ± 11,39 years. 94.74% of the carcinomas were endometrioid type, only one person with uterine serous carcinoma and one person with mixed endometrial carcinoma: 7 high grade (G3), 31 low grade (G1-G2). At surgery, DMI was found in 50% of the specimens. The DTA of 3D-TVS for the evaluation of DMI was 76.32% with SE 78.94% (54.43% to 93.95%) and SP 73.68% (48.80% to 90.85%). MRI showed a DTA of 78.94% for DMI, with SE of 84.21% (60.42% to 96.62%) and SP of 73.68% (48.80% to 90.85%).

Conclusion 3D-TVS demonstrated good diagnostic accuracy in terms of sensitivity and specificity for the evaluation of DMI, with results comparable with those of MRI. Considering its accessibility, cost-effectiveness and non-invasiveness, 3D-TVS could represent a valid alternative, with worthy clinical potential in the preoperative staging and surgery planning in patients with EC.

Disclosures None.