Article Text

Download PDFPDF
146 Granulosa cell tumors of the ovary: a retrospective study
  1. Imen Hamra,
  2. Mariem Garci,
  3. Mehdi Makni,
  4. Ameni Abdeljabbar,
  5. Nabil Mathlouthi,
  6. Cyrine Belgith and
  7. Olfa Slimani
  1. Charles Nicole University Hospital, Tunis, Tunisia


Introduction/Background Granulosa cell tumors (GCT) represent 5% of malignant ovarian tumors. Managing these tumors, which typically impact young women, necessitates recognizing the importance of preserving fertility. A precise preoperative diagnosis is essential to ensure appropriate treatment from the outset. The study aims to describe the clinicopathological features and outcomes associated with granulosa cell tumors.

Methodology This study is a retrospective analysis of eleven cases of ovarian granulosa cell tumors, collected over a 10-year period. The patients‘ characteristics, clinical, radiological, biological, and anatomopathological presentation, as well as their management and outcome, were studied.

Results There were 7 cases of adult-type GCT and 4 cases of juvenile-type tumors. The average age of the patients was 51 years for adult-type (AGCT) and 29 years for juvenile-type (JGCT). 36% of the patients were nulliparous, and 27% were menopausal. The clinical symptoms were dominated by abdominal-pelvic pain, often associated with hormonal manifestations such as abnormal uterine bleeding. The average tumor size was 10 cm with a solid-cystic appearance in 72% of cases. An association with endometrial pathology was found in 3 patients. Surgical treatment was performed in all cases. Among the 11 patients, 9 (81.8%) were diagnosed at stage IA. Conservative treatment with staging was performed in 75% of JGCT cases, and radical treatment was performed in all AGCT cases. Chemotherapy was indicated for 3 patients, but only the patient with JGCT received chemotherapy based on Etoposide-Bleomycin-Cisplatin (6 cycles). No relapse or recurrence was observed. Recurrence-free survival was 100% at 5 years. Surveillance included clinical examination, abdominal-pelvic CT scan, and the measurement of CA125 and inhibin B markers.

Conclusion Granulosa cell tumors are rare. Conservative treatment for early stages (stage I) with the goal of fertility preservation appears to be a reliable approach, provided that close monitoring can be ensured.

Disclosures The authors have no conflicts of interest to declare. All co-authors have seen and agree with the contents of the manuscript and there is no financial interest to report.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.