Introduction/Background Primary Fallopian Tube Cancer (PFTC) is a rare gynecologic malignancy since no screening tool is available as of date to clinch its diagnosis. This paper aims to raise awareness on PFTC; a neoplastic disease that can arise in patients diagnosed with breast cancer as well as those with a strong familial history of breast and ovarian cancer.

Methodology According to literature, the median age predisposed to have the disease is 55 years old however, this paper presents 2 reproductive aged women who were initially managed as cases of tubo-ovarian masses that turned out to be fallopian tube cancer.

Results The first patient is a 29-year-old female with a preoperative diagnosis of pelvic endometriosis with endometrioma who underwent left oophorocystectomy, excision of endometriotic implants and chromotubation. Intraoperatively, a suspicious looking paratubal cyst on the right fallopian tube and a serosal bladder mass was seen and excised with histopathologic examination revealing a poorly differentiated malignancy originating from the fallopian tube.

The second patient is a 40-year-old female with an initial impression of a tubo-ovarian complex resistant to antibiotic therapy versus pelvic tuberculosis versus ovarian malignancy. She underwent diagnostic laparoscopy with bilateral salpingectomy with microsections from the right fallopian tube demonstrating the pre-malignant lesion, serous tubal intraepithelial carcinoma (STIC) and neoplastic cells favoring a high-grade serous carcinoma

Conclusion Primary fallopian tube cancer is considered to be rare and difficult to treat. Inherited deleterious mutations in BRCA1 and BRCA2 are major risk factors in the development of the disease. Although the incidence of PFTC is highest in the 60–64 years of age group, the case series demonstrates the possibility of PFTC occurring in younger age groups especially those with a high genetic predisposition to breast and ovarian cancer.

Disclosures No Disclosures.