Article Text

Download PDFPDF
53 Serological evaluation of mucins in ovarian cancer
  1. Amar Ranjan and
  2. Harshita Dubry
  1. All India Institute of Medical Sciences, New Delhi, India


Introduction/Background Ovarian cancer (OC) is a lethal malignancy that lacks a sensitive biomarker for diagnosis and therapeutic monitoring. Mucin proteins (MUC) proteins have played a promising role as a diagnostic biomarker. We analyzed MUC1 and MUC4 for this purpose.

Methodology We analyzed 31cases of OC and 8 benign ovarian cysts. Pre-therapy whole blood sample was taken and serum levels of MUC1, MUC4 & MUC 16 (CA 125) were evaluated. Cut off for MUC1 and MUC4 was set using ROC curve analysis at highest sensitivity and specificity, 141.3ng/mL and 1.206ng/mL respectively. The values were compared with CA125 (established cutoff 35 U/ml).

Results Serum level of MUC1 was higher in 33/39 cases (28/31 in malignant cases, 3/8 in benign cases).

However, serum level of MUC4 was lower in 33/39 cases (26/31 in malignant cases, 5/8 in benign cases).

CA125 was higher in 33/39 cases (28/31 in malignant cases, 4/8 in benign cases).Higher levels of MUC1 were seen in HGSC, mucinous, endometriod, clear cell type of OC 16, 4, 3 & 2 respectively (p-value 0.567). Lower level of MUC4 was associated with diagnosis of ovarian cancer (p=0.9709). Higher level of CA125 was associated with cancer (p=0.0025), Type 2 tumor (p= 0.0013), advanced stage (p= 0.0087) and presence of omental metastasis (p= 0.0311).

The sensitivity and specificity of CA125 in this study was 90.32% and 62.5% respectively, for MUC1 90.32% and 50% respectively and for MUC4 83.87% and 37.5% respectively.

Conclusion Serum level of Mucin 1 was increased in ovarian cancer, while that of MUC4 was decreased in OC. A combined panel of mucin 1, MUC4 and ca125 can aid in better diagnosis of OC.

Disclosures N/A

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.