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49 Is minimally invasive surgical approach a reasonable option in apparent early stage epithelial ovarian cancer restaging? Results from a multicentric retrospective study
  1. Navid Mokarram Dorri1,
  2. Mathilde Del2,
  3. Francesco Cannone3,
  4. Manon Lefebvre4,
  5. Cecile Loaec5,
  6. Laura Sabiani1,
  7. Camille Jauffret1,
  8. Guillaume Blache1,
  9. Xavier Carcopino6,
  10. Jean Marc Classe7,
  11. Fabrice Narducci8,
  12. Alejandra Martinez9 and
  13. Eric Lambaudie10
  1. 1Institut Paoli Calmettes, Marseille, France
  2. 2IUCT, Toulouse, France
  3. 3Azienda di Rilievo Nazionale e Alta Specializzazione (ARNAS) Garibaldi, Catania, Italy
  4. 4Centre Oscar Lambret, Lille, France
  5. 5Institut de Cancerologie de l’Ouest, Nantes, France
  6. 6Hôpital Nord, Marseille, France
  7. 7APHM, Nantes, France
  8. 8Institut de Cancerologie de l’Ouest, Lille, France
  9. 9Centre Oscar Lambret, Toulouse, France
  10. 10IUCT, Marseille, France


Introduction/Background To perform surgical staging of early stage ovarian cancer (EOC), conventionnal laparoscopy (LS) and robot-assisted laparoscopy (RLS) appear to be reliable procedures compared to open surgery. But oncologicals results with long-term follow up are limited in the literature. The objective of this study is to evaluate the surgical and long-term survival for patients managed by minimally invasive surgery (MIS).

Methodology We conducted a multicentric retrospective study in 6 institutions. All patients refered for epithelial EOC (apparent stage I-IIa) managed with LS and RLS were involved.

Results From December 2008 to December 2017, 140 patients were included (109 in LS group and 31 in RLS group). A total of 27 (19.2%) patients were upstaged to an advanced ovarian cancer, and 73% of patients received chemotherapy. Mean operative time was 265,8 ± 88,4 min and significantly longer in RLS group (LS = 254,5 ± 86,8 ; RLS = 305,6 ± 85,5 ; p = 0,008). Post-operative complications were mainly grade 1 and 2 (LS : 20,2% and RLS : 29%). Thirteen conversion to laparotomy occurred, including one per-operative hemorrhaege. After a mean follow-up of 60,7 months, 29 (20.7%) patients recurred, with a time to recurrence was > 24 months in 51,7% of cases. Overall survival (OS) was 79,3% and disease-free survival (DFS) was 88,6%. Oncologic outcomes were similar between LS and RLS group.

Conclusion Surgical staging of EOC by LS or RLS approach has long-term equivalent surgical and oncological approach. These results seem to be equivalent to open surgery according to literature review.

Disclosures No discosures to report.

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