Introduction/Background Implementation of ultra-radical surgery on advanced epithelial ovarian cancer sets high criteria for patients who are offered surgical treatment. We wanted to evaluate the effect of changed criteria for patient selection for surgical treatment to the rate of surgically and non-surgically treated patients and assess the survival of patients who are not able to undergo surgical treatment.

Methodology We collected retrospectively all 333 patients diagnosed with FIGO stage III-IV epithelial ovarian cancer between 2013 and 2019 in Tampere University Hospital, Finland. Patients were divided into two groups based on the date of diagnosis. Group 1 (n=162) consisted of patients diagnosed before March 2016 and Group 2 (n=171) patients diagnosed after that time point, when ultraradical surgery was implemented in our institution.

Results The rate of non-surgically treated patients did not differ between groups, 23.5% (38/162) in Group 1 and 28.1% (48/171) in Group 2 (p=0.38). The median follow-up time was 31 months in Group 1 and 34 months in Group 2. In Group 1, median OS was 14.1 months (95% CI 6.1 - 22.0) for patients without surgical treatment and 36.1 months (95% CI 30.0 - 42.1) for surgically treated patients (p<0.001). In Group 2, the corresponding numbers were 13.6 (95% CI 6.6 - 20.6) and 46.1 months (95% CI 36.2 - 56.1), p<0.001. There was no difference in OS between study groups in patients who did not receive surgical treatment (p=0.69).

Conclusion The implementation of ultra-radical surgery did not affect the proportion or overall survival of patients with advanced epithelial ovarian cancer who were not eligible for surgical treatment.

Disclosures No.