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955 Effect of a coriolus versicolor-based vaginal gel as a conservative treatment for HR-HPV-dependent HSIL in pregnant women
  1. Carmen Belén De La Torriente Benito1,
  2. Antonio Carballo García2,
  3. Ana Cristina Fernández Rísquez2,
  4. Jesús Joaquín Hijona Elósegui2 and
  5. Margarita Gil Andrés3
  1. 1Clínica Mencía, Salamanca, Spain
  2. 2Hospital Universitario Materno-Infantil, Jaén, Spain
  3. 3Álvaro Cunqueiro, Vigo, Spain

Abstract

Introduction/Background Human papilloma virus (HPV) infection is the most common venereal infection and the main causative agent of the 99% of cervical cancer cases. HPV persistence, particularly with genotype 16, may lead to different grade squamous intraepithelial lesions that can result in high-grade lesions (HSIL) and cervical cancer. Surgical excisional treatment of HSIL/CIN2 and 3 during pregnancy is contraindicated due to the high rate of complications, including probability of abortion and preterm birth. Thus, the management of an HSIL diagnose during pregnancy remains to be a challenge to both, the patient and the clinician. With these three clinical case reports, we aimed to evaluate the effect of a Coriolus versicolor-based vaginal gel in the conservative management of CIN2 lesions during pregnancy.

Methodology Here we present three clinical case reports involving pregnant women between 26 and 34 years old with high-risk HPV (HR-HPV) genotypes including 16, 18, 31, 39, and 45, and who were diagnosed with HSIL/CIN2–3 through colposcopy and biopsies. Patients were prescribed with Coriolus versicolor-based vaginal gel (1 cannula/day for 1 month + 1 cannula/alternate days for 2 months) gel as a conservative treatment. Follow-up colposcopy, cytology and HPV tests were performed over time for monitoring patients.

Results All patients showed a regression of CIN2/3 to CIN1 lesions. Two of them, achieved the regression after 3 months of conservative treatment with Coriolus versicolor-based vaginal gel and one the other patient after 6 months of conservative treatment with Coriolus versicolor-based vaginal gel. None of the patients reported any negative effect associated with the use of Coriolus versicolor-based vaginal gel.

Conclusion The Coriolus versicolor-based vaginal gel treatment leads to regression of HSIL/CIN2 in pregnant women with HR-HPV. This conservative treatment approach represents a clinical advantage in patients during their ’wait and see’ period who are not candidates for an excisional surgery.

Disclosures .

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