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479 Fertility-preserving treatment for borderline ovarian tumors: one cancer center retrospective study
  1. Sviatlana Y Shelkovich1 and
  2. Olga P Matylevich2
  1. 1Institute of Advanced Training and Retraining of Healthcare Personnel of Belarusian State Medical University, Minsk, Belarus
  2. 2NN Alexandrov National Cancer Centre of Belarus, Minsk, Belarus


Introduction/Background Borderline ovarian tumors (BOTs) are rare epithelial ovarian tumors with an incidence from 5 to 20%. The latest WHO classification describes them as atypical proliferative tumors. Approximately one-third of all BOT are diagnosed in patients with child-bearing potential. Reproductive outcomes have not been well studied. The aim of this study was to analyzed the possibility of implementing reproductive function in young patients with BOTs after organ-preserving surgical treatment.

Methodology In retrospective study 40 patients with BOTs treated at the single oncology center from 2005 to 2013 were analyzed.

Results The average age was 28.2 years. Regarding the histological subtypes, 31 (77.5%) had serous, 8 (20.0%) had mucinous and 1 (2.5%) woman had mixed BOT.

All women underwent surgery. In a total of 30 women (75.0%) a complete surgical staging for BOT was performed, 10 (25.0%) patients initially were treated in non-specialized hospital and refused to underwent complete surgical staging. Fertility-preserving surgery was carried out in all patients.

Distribution by stages were as following: 25 (62.5%) – IA Stage, 5 (12.5%) – IB, 9 (22.5%) – IC, 1 (2.5%) – IIIB.

The follow-up period was more than 5 years.

Of the 40 patients included in the study, 14 already had children, among them pregnancy after surgery occurred in 4 (28.6%) women, 1 (7.14%) patient gave birth. The remaining 26 did not give birth. In this group, 19 (73.0%) patients became pregnant and 18 (69.2%) of them gave birth. All women delivered by cesarean section. 10 (52.6%) patients lactated. No relapses were detected during pregnancy and lactation.

During follow-up period 13 (32.5%) patients had recurrent benign ovarian cysts. 3 (7.5%) women showed a recurrence of BOT with no lethal outcome.

Conclusion Fertility-sparing approach in patients of reproductive age with BOTs can be justified without the risk of progression after thorough consultation.

Disclosures We have nothing to disclose.

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