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#1334 Improving earlier detection of endometrial cancer in black women in the UK: a review and proposed study
  1. Ojone Illah1,
  2. Iona Evans1,
  3. Allison Jones1,
  4. Daniel Reisel1,
  5. Osama Naji2,
  6. Jackie Ross3,
  7. Adeola Olaitan1 and
  8. Martin Widschwendter1
  1. 1Department of Womens Cancer, Institute of Womens Health, University College London, London, UK
  2. 2Department of Gynaecology, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
  3. 3Department of Gynaecology, Kings College Hospital NHS Foundation Trust, London, UK

Abstract

Introduction/Background In multi-ethnic populations including the UK and US, black women have a lower incidence of endometrial cancer (EC) but suffer with much higher death rates compared to white women. Recent Office of National Statistics (ONS) data shows that EC mortality in black women in the UK from 2015-2019 was more than double that of white women. This disparity in EC mortality is well reported and represents one of the worst racial disparities seen amongst all cancers.

A significant contributor to this disparity is that black women in the UK are twice more likely to be diagnosed with advanced stage EC compared to white women. It has been reported that transvaginal ultrasound (TVS), an important component of the EC diagnostic pathway, performs poorly for detecting EC in black women. Our study plans to investigate the use of an epigenetic-based test, the WID™-qEC test, for EC detection in black women.

Methodology Prospective cohort study of 200 black women aged >50 with abnormal vaginal bleeding, presenting to rapid access clinics in two London hospitals with a large black population.

A high vaginal swab will be collected from each participant to assess (WID™-qEC test) the methylation status of two genes known to be associated with EC.

Results Results from TVS, histology and WID™-qEC test will be collated for comparison and to determine the performance (sensitivity, specificity, positive PPV, NPV) of the WID™-qEC test for EC detection in black women.

Conclusion If successful, we hope that the outcomes from this study can lead to larger trials that may see such epigenetic-based tests introduced into clinical practice. At the minimum, we hope to stimulate the conduct of more cancer research in diverse ethnic groups, to improve outcomes in all populations and encourage the use of ethnicity-adjusted evidence-based medicine.

Disclosures None.

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