Introduction/Background There is paucity of long term collected data from India of comprehensively staged high grade endometrial cancer. This is a retrospective study of high-grade endometrial cancer over a period of 10 years at a tertiary care hospital in gynaecologic oncology department.

Methodology 84 patients underwent surgical staging including pelvic lymphadenectomy with or without para-aortic lymphadenectomy. Adjuvant chemotherapy, pelvic radiotherapy and brachytherapy were given to patients based on risk factors.

Results The median age was 64 years. 42(50.59%) patients were early stage, and 42(49.41%) patients were advanced stage. Of the advanced stage, 17 (20.2%) patients received neoadjuvant chemotherapy. 49(58.33%) patients had non endometroid histology. The median follow up was 73 months 27 patients. (32.1%) had lymph node positivity. 13 out of 27 patients (48.1 %) with pelvic node metastasis also had para-aortic involvement. 3 patients (11 %) had isolated para-aortic lymph node metastasis. 19 (22.6%) recurrences were reported with majority being distant recurrences. 3- and 5-year DFS was 76.66% and 66.67 % and 3- and 5-year OS was 90 % and 76.47 % respectively. Lymph-vascular invasion was significant predictor of recurrence. Multivariate analysis of prognostic parameters impacting survival was done.

Conclusion With appropriate staging and risk-based adjuvant treatment, there is potential to achieve good survival outcomes in high grade endometrial cancers.

Disclosures No disclosures.