Introduction/Background Objective: The aim of this study was to investigate the beneficial aspects of different operative approaches in the treatment of presumed stage I endometrial cancer.

Methodology Method: Preliminary results of a monocentric, retrospective study (the intended period of analysis will cover a timeframe of 10 years or more) currently include data from the years 2012 to 2014, involving 51 patients. Thirty-nine (76.5%) were treated by laparoscopic-assisted vaginal hysterectomy (LAVH) + bilateral salpingo-oophorectomy (BSO) and 12 (23.5%) by total abdominal hysterectomy (TAH) + BSO, and total laparoscopic hysterectomy (TLH) + BSO; majority of patients underwent pelvic lymphadenectomy (n=48; 94%).

Due to the smaller number of patients operated with the TAH (total abdominal hysterectomy) and TLH (total laparoscopic hysterectomy) methods, we decided to combine them into the same group.

Results Results: With the exception of one patient, all others had endometrial endometrioid carcinoma; the majority of patients (n=46) had stage I disease (FIGO staging of endometrial cancer). Five patients (9.8%) had recurrence of disease (three of them had stage 1B disease, one had stage 1C, and one had stage 2), 2 out of those 5 patients were operated with LAVH + BSO surgery. All disease recurrences occurred in female patients aged 65 and older. Statistically significantly shorter hospitalization was observed in patients operated with the LAVH + BSO surgery.

Conclusion Conclusion: Given the fact that these are preliminary, incomplete data based on a small sample, we would refrain from drawing conclusions; however, we observed a statistically significant shorter hospitalization in patients operated with the LAVH +BSO method.

Disclosures Nothing to declare.