Introduction/Background Clear cell carcinoma is a histologically rare type(about 1–5.5%) of endometrial cancer. Compared with endometrioid type, patients with CCC have a worse prognosis. Due to the low incidence rate of CCC of the endometrium, data on prognosis-related factors of CCC is still controversial

This study evaluated the oncological outcomes and the impact of clinicopathological factors on the prognosis of endometrial clear cell carcinoma (ECCC)

Methodology Between 2005 and 2021, Seventy-three ECCC patients, diagnosed and treated, were reviewed retrospectively. Cox proportional hazards regression was used to identify potential prognostic factors. According to the risk factors, survival curves were compared using the Kaplan-Meier method.

Results The median follow-up time was 39.6 months, and the median age at diagnosis was 59.0 years. Thirty-nine (53.4%) women had early-stage disease, and 34 (46.6%) women had advanced-stage disease. Minimally invasive surgery was done performed on 32 patients (45.1%). Of the patients, 32 (43.8%) had pure clear cell carcinoma, while 41 (56.2 %) had mixed histology in the hysterectomy specimen. 22 patients (31%) had lymph node metastasis and fifteen (20.5%) patients had ovarian metastasis. In 13 patients (16.5%), mismatch repair protein(MMRP) status was evaluated and among them 4 patients (30.8%) had MMRP dificeincy . In 23 patients (32.4%), P53 status was evaluated and among them, 19 patients (82.6%) had P53 positive .. The mean disease-free survival (DFS) and overall survival(OS) were 38.2 and 46.4months, respectively. The recurrence rate was 28.1%, and the death rate was 13.6%.

Conclusion In our series of ECCC, we did not found independent poor prognostic factor for survival. However, ECCC exhibited a high frequency of ovarian metastasis postoperatively and MIS was not affect the survival outcomes.

Disclosures None.