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857 Endometrial cancer incidence in patients with atypical endometrial hyperplasia
  1. Nour El Houda Mekkaoui
  1. CHU Hassan II GO I, Fes, Morocco

Abstract

Introduction/Background Atypical endometrial hyperplasia is defined as histologically abnormal overgrowth of the endometrial glands and can be a precursor to cancer. It is a real precancerous lesion, which may even be associated with endometrial adenocarcinoma, even if the hysteroscopy does not find lesions suggestive of carcinoma.

Methodology We conducted a retrospective study over 7 years, including 28 patients who were diagnosed with atypical endometrial hyperplasia after anatomopathological study of a biopsy curettage of the endometrial.

The objectives of this study is to determine the incidence of endometrial cancer in patients undergoing hysterectomy for atypical complex endometrial hyperplasia diagnosed by hysterosopy with multiple endometrial biopsies, and compare our results to those in the literature.

Results The treatement consisted of total hysterectomy with bilateral adnexectomy.The final anatomopathological report came back in favor of endometroid adenocarcinoma in 3 patients.

The other histological types which have been found are: Atypical endometrial hyperplasia in 64% of cases, simple non-atypical hyperplasia, focally complex and atypical endometrial in 21% of cases, and simple non-atypical endometrial hyperplasia in 3 % of cases .

Conclusion In conclusion, the risk of concurrent malignancy was 10.7 % in patients who had been diagnosed with atypical endometrial hyperplasia based on biopsy curettage of the endometrial.

Total hysterectomy stay the safest first line of treatment in atypical endometrial hyperplasia due to the high risk of concurrent endometrial cancer and progression to endometrial cancer.

Disclosures The authors declare that they have no conflict of interest.

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