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773 Sentinel node biopsy in endometrial cancer. Results after ten years in donostia university hospital
  1. María Del Mar Rubio,
  2. Mikel Gorostidi,
  3. Ibon Jaunarena,
  4. Juan Cespedes,
  5. Ruben Ruiz,
  6. Paloma Cobas and
  7. Arantxa Lekuona
  1. Donostia University Hospital, Donostia, Spain

Abstract

Introduction/Background Endometrial cancer (EC) is the most common gynecologic neoplasm in developed countries. In recent years, the staging of the lymph node has been modified, with the incorporation of sentinel lymph node biopsy (SNB), allowing a reduction in the number of lymphadenectomies performed and consequently their complications. This study aims to analyze the results in our center before and after the incorporation of this technique.

Methodology A retrospective cohort study was designed to compare patients with early-stage endometrial cancer (I-II) treated with the previous protocol (lymphadenectomy) versus those operated on after BSGC validation at the University Hospital of Donostia, between June 2014 and July 2022, including a total of 376 patients.

The inverse weighting of treatment probability was used to minimize biases derived from the absence of randomization, and a propensity score was applied using the R statistical software.

Results A total of 376 patients who underwent surgery for CE were identified; 11.7% with the SNB protocol. In the latter, no lymphadenectomy was performed, compared to a lymphadenectomy rate of 53.54% in the other cohort; In addition, a significant reduction in days of admission (from 1.53 to 0.65 days less) and intraoperative bleeding (15.3% reduction) was observed. Higher rates of bilateral pelvic lymph node detection were observed (90.48% vs. 68.96%). Detection rates of aortic SN were not lower (83.33% vs. 68.23%) and overall detection rates (bilateral pelvic CG with aortic SN) improved from 53.83% to 73.81%.

Conclusion The incorporation of SNB into the treatment of EC improves sentinel node detection rates, significantly reducing the number of lymphadenectomies, hospital stays, and blood loss.

Disclosures Selective sentinel lymph node biopsy reduces the number of lymphadenectomies, hospital stays, and blood loss.

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