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772 Reviving peritoneal cytology: exploring its role in endometrial cancer molecular classification
  1. Selma Zurbriggen1,
  2. Anna Sophie Villiger2,
  3. Sara Imboden2,
  4. Wiebke Solass3,
  5. Lucine Christe3,
  6. Flurina Saner2,
  7. Gmür Andrea2,
  8. Tilman T Rau4,
  9. Michael D Mueller2 and
  10. Franziska Siegenthaler2
  1. 1University of Bern, Bern, Switzerland
  2. 2Department of Obstetrics and Gynecology, Bern University Hospital and University of Bern, Bern, Switzerland
  3. 3Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland
  4. 4Institute of Pathology, Universitätsklinikum Düsseldorf, Düsseldorf, Germany


Introduction/Background The prognostic significance of positive peritoneal cytology in endometrial cancer has long been debated. In 2009, the Fédération Internationale de Gynécologie et d’Obstétrique (FIGO) removed cytology as a staging criterion from the endometrial cancer staging system. However, there is still evidence that positive peritoneal cytology may decrease survival among patients with endometrial cancer. The aim of this study was to determine the prognostic significance of positive peritoneal cytology among the different molecular subgroups.

Methodology This study included patients with endometrial cancer who underwent primary surgical treatment between 2004 and 2015 at the Bern University Hospital, Switzerland, with molecular classification of the primary tumor and peritoneal cytology performed.

Results A total, 250 patients with endometrial cancer were enrolled. Peritoneal cytology was assessed in 206 patients, of whom 24% were positive: 25% of the POLEmut, 16% of the MMRd, 41% of the p53abn, and 24% of the NSMP cases. The mean follow-up was 128.7 months. Presence of positive peritoneal cytology was associated with significantly decreased mean recurrence-free and overall survival in patients with p53abn (p = .003 and p = .001) and NSMP (p = .020 and p = .049) endometrial cancer. In multivariable Cox regression analysis, positive peritoneal cytology remained an independent predictor of recurrence (p = .033) and death (p= .008) in p53abn endometrial cancer patients.

Conclusion Positive peritoneal cytology is associated with worse oncologic outcomes in NSMP and p53abn endometrial cancer and remains an independent predictor of recurrence and death in patients with p53abn endometrial cancer.

Disclosures No disclosures.

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