Introduction/Background The epidemiology of cancers in terms of incidence and mortality are different in the French overseas compared to mainland France. We reported clinic-pathological features and outcomes from population with endometrial carcinoma (EC) from three french overseas territories (Martinique, French Polynesia (FP) and Wallis and Futuna (WF).

Methodology We performed an academic retrospective study on patients with EC in Martinique, FP and WF. Progression-free survival (PFS) and overall survival (OS) were estimated by the Kaplan-Meier method in each population.

Results Overall, 372 patients from FP, 72 from Martinique and 43 from WF were included in the analysis.

Martinique cohort: Median age was 79.5 (57–90). Median BMI was 33.4 kg/m2. Histology was endometrioid in 51%, serous in 40%, clear cell in 3%, and mixed in 3%; 16.7% pts had dMMR and 45.8% TP53 mutated tumors. FIGO stage at diagnosis was I, II, III and IV in 44%, 4.1%, 23.7%, 25% respectively. The five years OS of the global population was 65% (95%IC 57.1–74.5).

FP cohort: Median age was 58 (20 - 88). Median BMI was 34.6 kg/m2. Histology was endometrioid in 80%, serous in 6% and clear cell in 2%. FIGO stage at diagnosis was I, II, III and IV in 51.7%, 6.5%, 12.1%, 14.5% respectively. The five years OS of the global population was 60.8% (95%IC 54.2–68.2).

WF cohort: median age at diagnosis was 56 (47–65.5). Median BMI was 37. Histology was predominantly endometrioid (over 88%), serous (7%) and clear cell or carcinosarcoma (2.3%). FIGO stage was I (over 80%), III (9.3%) and II or IV (2.3%). The OS at 5 years of the global population was 76.4% (95% CI 61.9–94.2).

Conclusion We reported for the first time, 3 overseas french population of EC. FP and WF patients were younger associated to high obesity prevalence. In Martinique, histology was unusual with 40% serous.

Disclosures None.