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182 Associations between modifiable lifestyle factors and health-related quality of life among endometrial carcinoma survivors – a cross-sectional study
  1. Linn Øvstebø Opheim1,2,
  2. Ida Engeskaug1,2,
  3. Pernille Bjerre Trent1,3,
  4. Lene Thorsen4,5,
  5. Anne Cathrine Staff3,6,
  6. Nina Jebens Nordskar7,8,
  7. Inger Utne2,
  8. Milada Hagen2 and
  9. Ane Gerda Zahl Eriksson1,3
  1. 1Department of Gynecologic Oncology, Division of Cancer Medicine, Oslo University Hospital, Norwegian Radium Hospital, Oslo, Norway
  2. 2Department of Nursing and Health Promotion, Faculty of Health Sciences, OsloMet – Oslo Metropolitan University, Oslo, Norway
  3. 3Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
  4. 4National Advisory Unit on Late Effects after Cancer Treatment, Department of Oncology, Oslo University Hospital, Oslo, Norway
  5. 5Department of Clinical Service, Division of Cancer Medicine, Oslo University Hospital, Oslo, Norway
  6. 6Division of Obstetrics and Gynaecology, Oslo University Hospital, Oslo, Norway
  7. 7Section of Gynecologic Oncology, Dept. of Obstetrics and Gynecology, St Olav’s Hospital, Trondheim University Hospital, Trondheim, Norway
  8. 8Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway


Introduction/Background To explore possible associations between modifiable lifestyle factors and health-related quality of life (HRQoL) in endometrial carcinoma survivors.

Methodology This was a cross-sectional population-based study in women having undergone surgery for assumed early-stage endometrial carcinoma. We assessed differences in HRQoL between survivors meeting and not meeting the World Health Organization‘s (WHO) recommendations regarding physical activity, BMI, and smoking. Novel thresholds for clinical importance based on the EORTC QoL working group were used to interpret scores. Effect size (ES) was interpreted as small (d=0.2–0.49), medium (d=0.5–0.8), and large (d>0.8).

Results In total, 1200 women were included. After adjusting for demographics- and disease related factors, meeting physical activity recommendations (46%) and BMI <25kg/m2 (32%) was associated with significantly better global health status (ES=0.18 and ES=-0.11, respectively). On multivariate analysis, women meeting physical activity recommendations had significantly higher scores on physical- (ES=0.31), role- (ES=0.15), and social functioning (ES=0.15), and lower levels of fatigue (ES=-0.16), pain (ES=-0.10), and appetite loss (ES=-0.15) (all p<0.05) compared to non-meeting survivors. Participants with BMI ≥25kg/m2 had lower scores for social functioning (ES=-0.10), and higher levels of pain (ES=0.13) and dyspnea (ES=0.12) (all p<0.05) compared to those with BMI <25kg/m2. Smokers had lower scores for emotional functioning (ES=-0.09) and higher levels of diarrhea (ES=0.10) (all p<0.05) compared to non-smokers. Figure 1 shows proportions of women over thresholds for clinical importance, stratified by if they met WHO recommendations or not. Bars in dark green and light red represent women meeting WHO recommendations.

Conclusion Meeting WHO recommendations for modifiable lifestyle factors is associated with better HRQoL among endometrial carcinoma survivors. Being sufficiently physical active and having a BMI <25kg/m2 are significantly associated with better self-reported global health status. All modifiable factors are associated with better functioning, and reduced symptom burden. This should be communicated to endometrial cancer survivors during treatment and surveillance.

Disclosures None.

Abstract 182 Figure 1

(A) EORTC QLQ-C30 functional scales. (B) EORTC QLQ-C30 symptom scales

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