Introduction/Background In Republic of Kazakhstan, endometrial cancer among malignant tumors occupies the 9th ranking position, and in the structure of gynecological cancer, the 3rd place, about 1000 cases of this disease are detected annually.

Methodology This study is a retrospective analysis of patients with endometrial cancer (EC) who underwent sentinel lymph node (SLN) mapping at the Kazakhstan Institute of Oncology and Radiology (KazIOR) between January 1, 2021, and December 30, 2021. The primary objective is to assess the feasibility and safety of SLN mapping in patients with early-stage EC.

Results In the period from January 1, 2021 to December 30, 2021, 37 patients with detection of sentinel lymph nodes were registered in KazIOR. The mean age of the patients was 52 years. The average body mass index of patients was 30.2 kg/m². Preoperative assessment of endometrial cancer risk groups showed: low risk in 19 (51.3%) patients, intermediate risk in 11 (29.7%) patients, high risk in 7 (18.9%) patients. Complete pelvic and para-aortic lymph node dissection was performed in 7 (18.9%). In 30 (81%) patients, at least one sentinel lymph node was successfully mapped. 7 (18.9%) patients had positive nodes. In 37 patients, no postoperative complications were detected. The final histology revealed: 31 (83.7%) patients had endometrioid adenocarcinoma, 6 (16.2%) had clear cell carcinoma.

Conclusion This study confirms the feasibility of the SLN procedure to assess recurrence risk in patients with early EC and the safety of sentinel lymph node detection.

Disclosures No disclosures.