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845 Late local breast cancer recurrence: a single center experience
  1. Oumeima Khaldi1,
  2. Fatma Saadallah2,
  3. Sarra Ben Ltaief1,
  4. Salma Kammoun1,
  5. Ines Zemni3 and
  6. Tarek Dhieb1
  1. 1Salah Azaiez Institut, Tunis, Tunisia
  2. 2Carcinologic Surgical Department, Salah Azeiz Institute, Tunis, Tunisia
  3. 3Department of Surgical Oncology, Salah Azaïz Institute, Faculty of Medicine, Tunis, Tunisia


Introduction/Background Although breast cancer treatments have made great strides in recent decades, there are still late local breast cancer recurrence (LLBCR), occurring 10 years or more after the primary diagnosis.

With the increasing number of breast cancer survivors, further characterization of the risk of late breast cancer recurrence remains of key importance in guiding clinical management.

We herein report our experience in the management of LLBCR in a North African center.

Methodology This study included retrospectively 19 patients diagnosed with non-metastatic LLBCR after conservative breast surgery in Salah Azaiez Institut between 2004 and 2023.

Results All our patients had breast conservative therapy. Chemotherapy was indicated in 16 cases. and 15 women had adjuvant hormonotherapy.

Histologic types were as follows: 18 infiltrating ductal carcinomas and one mixt infiltrating carcinoma. Grade distribution according to SBR classification was as follows: 3 grade 1, 8 grade 2, 8 grade 3. The mean tumor size was 32 mm. The most frequent immunochemical profile was luminal B. The intra-ductal component was present in 6 patients. Margins were assessed and were negative in all cases. Peri-tumoral vascular invasion was observed in 6 patients.

The mean age at recurrence was 51 years. The mean interval from the beginning of treatment and the diagnosis of local recurrences was 160 months. After local recurrence, salvage mastectomy was performed in all patients, and systemic hormonal therapy was administered to 4 patients. Overall survival after LLBCR was estimated to 23 months.

We studied the impact of age, initial tumor size, disease stage, histological grade, presence of lympho-vascular invasion, and presence of intra-ductal component but no statistical significance was found.

Conclusion This study failed to identify predictive factors of LLBCR. Further studies including a bigger population are needed to identify patients requiring long-term hormonotherapy and careful follow-up.

Disclosures Authors have nothing to disslose.

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