Introduction/Background We conducted a retrospective analysis of data of 35 cases with patients treated at the Republican Scientific Center of Oncology of the RUz for primarily multiple metachronous neoplasms of the reproductive system organs.

The purpose is to analyze the diagnostics, clinical course and treatment of polyneoplasia with the intention to improve the results of diagnostic measures.

Methodology Materials and methods. The main contingent – 94.3% (33 patients) aged 40–60. In the oncological aspect, this age category is characterized as the highest frequency of disorders in menstrual-ovarian function and endocrine metabolic processes. The average age of patients, at the time of detection of the first malignant tumor, was 46.3.

Results Among patients with ovarian cancer in combination with breast tumor – 77.2% (27), metachronous occurrences of two malignant tumors were indicated.

Moreover, in 91.4% (32) ovarian cancer was diagnosed as a second malignant neoplasm. The interval for the development of the second tumor was 3–15 years. Besides, within the first 3 years it occurred in 40% (14). When analyzing various combinations of primarily multiple neoplasms, 77.1% (27) were classified as hormone-dependent tumors. 71.4% (25) had obesity, diabetes, hypertension, infertility, anovulation and thyroid pathology.

Conclusion Determined proximity of the pathogenetic mechanisms of reproductive system malignant tumors specifies the high percentage of metachronous neoplasms in patients with ovarian cancer. Withal, it was noted that when ovarian cancer occurs as part of polyneoplasia, the main lesions are concentrated in reproductive homeostasis. Search for a tumor in every patient with endocrine disorders and genetic predisposition should aim 4 organs: the endometrium, ovaries, cervix and breast. An in-depth examination of patients isindicated before and after treatment for solitary cancer of each organ of the reproductive system. In perspective, patients need periodic examinations throughout their lives – at least 1–2 times a year.

Disclosures Legal entity responsible for the study: Nozima Umarova.

Funding Has not received any funding.

Disclosure All authors have declared no conflicts of interest.