Introduction/Background The synchronous occurrence of multiple primary neoplasms, particularly across different organs like breast and cervix, presents complex diagnostic and therapeutic challenges. While breast cancer commonly coexists with various malignancies in women, the simultaneous manifestation of breast cancer alongside cervical cancer is exceedingly rare due to diverse etiological factors. Identifying synchronous cancers is intricate, and advanced imaging modalities address this diagnostic complexity. This case report highlights a 41-year-old woman diagnosed with simultaneous cT2N2M0, IIIA staging multicentric breast carcinoma and Grade 2 cervical carcinoma, underlining the necessity for individualized and comprehensive care.

Methodology The patient underwent comprehensive assessments confirming synchronous cervical and breast cancers. A multidisciplinary team involving gynecological oncology, surgical oncology, radiation oncology, and interstitial brachytherapy specialists collaborated to design a tailored treatment plan.

Results Diagnostic evaluations confirmed synchronous cervical and breast cancers. The treatment strategy encompassed neo-adjuvant chemotherapy followed by mastectomy for breast cancer. Simultaneously, the patient received radio-chemotherapy for cervical cancer, supplemented by interstitial brachytherapy. Subsequent follow-ups revealed no clinical recurrence, indicating a favorable response to the combined treatment modalities.

Conclusion Managing synchronous multicentric breast carcinoma and cervical carcinoma in a 41-year-old woman necessitated a personalized multidisciplinary approach. Tailored treatments including surgery, radio-chemotherapy, and adjunctive interstitial brachytherapy were instrumental in achieving positive outcomes. This case underscores the significance of meticulous planning, interdisciplinary collaboration, and personalized strategies for the optimal management of rare synchronous dual malignancies.

Disclosures No specific disclosures or conflicts of interest are reported for this case.