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1271 Primary sarcoma of the cervix: Salah Azaiez institute experience
  1. Azza Chabchoub,
  2. Maha Chrigui,
  3. Amine Bouida,
  4. Maher Slimene and
  5. Tarek Dhieb
  1. Salah Azaiez Institute, Tunis, Tunisia


Introduction/Background Primary sarcoma of the cervix accounts for less than 1% of all cervical cancers originating from the cervix’s mesenchymal tissue.

Methodology This retrospective observational study conducted at the Salah Azaiez Institute aimed to examine the institute’s experience in managing primary high-grade cervical sarcomas over a 20-year period. The study included 10 patients, with 8 medical files providing usable data.

Results The median age of the patients was 54 years, with the majority (87.5%) being over 45 years old. The most common histological type observed was leiomyosarcoma (75%), followed by stromal sarcoma and adenosarcoma.

The main presenting symptoms were bleeding (87.5%) and leucorrhoea (12.5%). 62.5% of patients had Enlarged cervix upon clinical examination, and 12.5% of patients were metastatic at the time of presentation.

Multidisciplinary consultations led to treatment decisions, with 87.5% of patients undergoing surgery, while one patient received chemotherapy elsewhere.

Surgical procedures included hysterectomy with bilateral adnexectomy, enlarged colpohysterectomy, and pelvic recurrence excision.

Complications were rare, with only one patient experiencing a rectovaginal fistula. Postoperative radiotherapy was administered to 25% of patients, and two patients received postoperative ADRIA-based chemotherapy with limited tolerability.

During an average follow-up of 8 months, 25% of patients died, 37.5% of patients experienced recurrence, and only one of 8 patients remained in apparent good health.

Conclusion Primary sarcoma of the cervix presents diagnostic and therapeutic challenges due to its rarity, poor prognosis, and limited treatment options. Early detection and comprehensive treatment remain vital for improving patient outcomes. Further research is necessary to enhance our understanding of this condition and develop more effective therapeutic strategies.

Disclosures None.

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