Introduction/Background Cervical Cancer is the most common cancer in the developing countries unlike the western world where the effective screening protocol has significantly reduced the number of cases. This study highlights the effectiveness on screening for reducing cervical cancer mortality and incidents alongside optimal timing and frequency of screening.

Methodology We searched MIDLINE, Embrace and cochrane central from 2000 to 2022 for relevant RCT and observation studies. Eligible studies included women age 20 to 65 years who were screened using conventional cytology liquid based cytology and HPV DNA testing.

Results Cytology screening was shown to be beneficial significantly the risk of being diagnose with invasive cervical cancer.

Conclusion The available evidence supports the conclusion that cervical screening does offers protective benefits and is associated with reduction in invasive cervical cancer and cancer mortality.

Disclosures None.