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921 Prognostic factors that influence global survival in patients with locally-advanced scamous cells cancer in our area
  1. Higinio Vidal Roncero,
  2. Javier Lopez Zajara,
  3. Jose Luis Colombo Garcia,
  4. Sandra Maria Lopez Dominguez,
  5. Gloria Reina Vinardell and
  6. Rafael Torrejon Cardoso
  1. Hospital Puerta del Mar, Cadiz, Spain


Introduction/Background Cervical cancer is the second most frequent cause of cancer in women worldwide, although in developed countries, thanks to early detection programs for cervical cancer, the incidence and mortality linked to this tumor has decreased considerably. Squamous cell carcinoma is the most common histological type.

Methodology We are going to realize an observational, descriptive, longitudinal and retrospective study of a series of cases of women with advanced local cervical cancer treated at the Puerta del Mar University Hospital between January 2013 and December 2017, using the medical records of the patients to obtain the necessary data through an anonymous database.

Results After collecting data in an Excell document, said data was coded in the SPSS Statistics 25 program to carry out the various analytical studies.

After applying exclusion criteria, a total of 52 patients were included in the study. The variables to be studied were age, histology, degree of differentiation, stage, size, parametrium involvement, lymph node metastasis, treatment received, months of survival

Conclusion Here are factors that have a predictive factor in the survival of patients with cervical cancer, these being the tumor stage, the presence or absence of lymph node metastases and the treatment received. These prognostic factors present significant differences, with significant variables being understood as those variables whose Long-Rank had a ‘p ‘value less than or equal to 0.05. On the other hand, prognosis had no significant correlation with age, histological type, degree of differentiation, tumor size, and parametrium invasion. In relation to the overall survival found in this study, no major differences are observed with the survival obtained by other studies.

However, the rest of the factors analyzed, including age, histological type, histological grade, tumor size and invasion of parametria, did not present a significant correlation with the prognosis.

Disclosures With this study is pretended to determinated what is the overall survival in patients with local cervical cancer - advanced treated in Cádiz and what prognostic factors can influence on it. Tumor stage, lymph node metastases, and treatment received are predictors of poor prognosis for cervical cancer, with both tumor stage and lymph node involvement being independent poor prognostic factors. However, there is no significant correlation between age, histological type, degree of tumor differentiation, tumor size and parametrial involvement and survival of patients with cervical cancer. But although there is no statistical association between these factors and survival, clinical differences are observed in terms of overall survival between groups.

This study could serve as a basis for future work where a larger sample size is used and other factors such as vascular invasion, depth of stromal invasion and infiltration of the lower third of the vagina are studied

Abstract 921 Table 1

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