Introduction/Background We performed this study to identify factors that could predict local disease-free survival (DFS) in patients treated with curative intent by Chemoradiotherapy (CT/RT) followed by Radical Surgery (RS) for locally advanced cervical cancer.

Methodology We conducted a retrospective study at Salah Azaiez Institute of Oncology from January 1, 2010, to December 31, 2020, including 122 patients managed with curative intent by CT/RT followed by RS for locally advanced cervical cancer. Clinical and pathologic variables were analyzed using univariate analyses. DFS was performed by the Kaplan-Meier method and the log-rank test.

Results 122 patients were treated with Chemoradiotherapy followed by radical surgery for locally advanced cervical cancer. The mean age was 54.16 years (34–82). 73 patients (59.8%) had a FIGO Stage≤IIB while 49 were ≥IIIA (40.2%). Among these cases, 13 patients (11.9%) presented loco-regional recurrence. Three-year local DFS was 87.2%. Histological grade p(0.034), lymphovascular space involvement (LVSI) p (0.000), FIGO stage p(0.007) parametrial involvement on specimen p(0.000), complete histological response on specimen p(0.011) and pelvic lymph node metastases p(0.000) were prognostic factors that affected local disease-free survival.

Local DFS was not significantly different for age p(0.607), tumor size p(0.267), and cell type p(0.489).

Conclusion Histological Grade, LVSI, FIGO stage, parametrial invasion on the specimen, complete histological response on the specimen, and pelvic lymph node metastases were prognostic factors for local DFS in locally advanced cervical cancer patients treated with Chemoradiotherapy followed by radical surgery.

Disclosures All authors declare that there are no conflicts of interest.