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759 Prognostic factors affecting distant disease-free-survival in locally advanced cervical cancer treated with chemoradiation followed by radical surgery
  1. Marwa Aloui1,
  2. Ines Zemni1,2,
  3. Nadia Boujelbene2,3,
  4. Souha Jaouadi1,
  5. Ines Zidi2,
  6. Mohamed Ali Ayadi1 and
  7. Tarek Ben Dhiab1
  1. 1Surgical Oncology Department, Salah Azaiez Institute of Oncologie, Faculty of Medicine of Tunis, Tunis, Tunisia
  2. 2LMBA (LR03ES03), Sciences Faculty of Tunis, University of Tunis El Manar, Tunis, Tunisia
  3. 3Pathology Department, Salah Azaiezz Institute, Faculty of Medicine of Tunis, Tunis, Tunisia

Abstract

Introduction/Background This study was performed to identify the factors that could predict distant disease-free survival (DFS) in patients treated with curative intent by Chemoradiotherapy (CT/RT) followed by Radical Surgery (RS) for locally advanced cervical cancer.

Methodology We conducted a retrospective study at Salah Azaiez Institute of Oncology from January 1, 2010, to December 31, 2020, including 122 patients managed with curative intent by CT/RT followed by RS for locally advanced cervical cancer. Clinical and pathologic variables were analyzed using univariate analyses. DFS was performed by the Kaplan-Meier method and the log-rank test.

Results 122 patients were treated with Chemoradiotherapy followed by radical surgery for locally advanced cervical cancer. The mean age was 54.16 years (34–82). Among these cases, 9 patients (7,4%) presented distant recurrence with a median time of 21.22 months (6–62). Five patients were FIGO stage ≥IIIA and 4 patients were FIGO ≤IIB. Five-year distant DFS was 87.2%. Age p(0.017), smoking p(0.016), bladder invasion on MRI p(0.017), histological grade p(0.027), lymphovascular space involvement (LVSI) p(0.000), parametrial invasion on specimen p(0.006) and pelvic lymph node metastases p(0.001) were prognostic factors that affected distant disease-free survival.

Distant DFS was not significantly different for tumor size p (0.126), cell type p (0.553), and FIGO stage p (0.176).

Conclusion Age, smoking, bladder invasion on MRI, LVSI, histological grade, parametrial invasion on specimen, and pelvic lymph node metastases were prognostic factors for distant DFS in locally advanced cervical cancer patients treated with Chemoradiotherapy followed by radical surgery.

Disclosures All authors declare that there are no conflicts of interest.

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