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696 Cervical cancer in Tunisian patients: clinical characteristics, survival, and prognostic factors
  1. Abid Wiem,
  2. Ayadi Hadhemi,
  3. Ben Hssine Samia,
  4. Jaffel Hajer and
  5. Mahjoub Najet
  1. Radiotherapy and Oncology Department, Jendouba, Tunisia


Introduction/Background The study aims to investigate the clinical characteristics and prognostic factors of cervical cancer and estimate the 3-year survival rates.

Methodology A retrospective study was conducted on patients treated for cervical cancer in 2020. Three-year survival rates were analyzed using the Kaplan-Meier method and compared using the Log-rank test. Prognostic factors were assessed through Cox regression analysis.

Results Fifty-six patients were treated for cervical cancer, with a median age of 57 years [33–86]. The median age of first sexual intercourse was 20 years [15–30]. Ten patients had a history of sexually transmitted infections. The most frequent clinical stage was IIB in 40% of cases. All patients received pelvic radiotherapy (RT) at a dose of 45 Gy [30–64.8] in 25 fractions [10–36]. The spread of radiotherapy was less than 1.5 months in 87% of cases. Ninety-three per cent received concurrent chemotherapy with radiotherapy. Radiochemotherapy was well-tolerated in 90% of cases, and 20% of patients experienced anaemia during treatment. Seventy-seven per cent of patients underwent low-dose-rate uterovaginal brachytherapy. The total duration from the start of radiotherapy to the end of brachytherapy was 49 days [12–90]. Fifty-three per cent underwent surgery. Responses after neoadjuvant treatment were as follows: complete response in 50% of cases, partial response in 33% of cases, and progressive disease in 17% of cases. The 3-year overall survival (OS) and progression-free survival (PFS) were 73% and 63%, respectively. In a multivariate analysis, factors correlated with poor OS were age >50 years (p=0.016) and duration between the start of RT and the end of brachytherapy >30 days (p=0.001). Factors correlated with poor PFS were locally advanced tumour stage (p=0.03) and the absence of a complete response after surgery (p=0.0001).

Conclusion Cervical cancer remains a public health issue in our country, emphasizing the need for a mass screening program.

Disclosures No financial interest.

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