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EP025/#623  Prognostic value of tumor-infiltrating lymphocyte score in early-stage triple-negative breast cancer: experience from a single center in vietnam
  1. Hoai Hoang1,
  2. Huyen Phung2,
  3. Ngoc Nguyen Tung3,
  4. Thach Nguyen Dinh4,
  5. Long Nguyen5 and
  6. Thang Nguyen1
  1. 1Hanoi Medical University, Department of Oncology, Hanoi, Viet Nam
  2. 2Vietnam National Cancer Hospital (K hospital), No6 Medical Oncology Department, Hanoi, Viet Nam
  3. 3Viet Duc hospital, Department of Pathology, Hanoi, Viet Nam
  4. 4Vietnam National Cancer Hospital, Department of Pathology, Hanoi, Viet Nam
  5. 5Vietnam National Cancer Hospital (K hospital), Medical Oncology Department No. 6, Hanoi, Viet Nam


Introduction To evaluate the prognostic value of tumor-infiltrating lymphocyte scores (TILs) and their correlation with clinicopathological features in patients with early-stage triple-negative breast cancer (TNBC) in Vietnam.

Methods A retrospective study on 105 patients with early-stage TNBC who did not undergo neoadjuvant systemic therapy in Vietnam National Cancer hospital from January 2018 to May 2019. TILs assessment and the density of CD8+ TILs on IHC in intratumoural (iTILs) and stromal compartments (sTILs) were evaluated on surgical specimens. The relationship between clinicopathological features and immunoreactivity was evaluated with Pearson’s Chi squared test or Fisher’s exact test using median TIL value as the cut-off. Overall survival (OS) was analyzed using the Kaplan-Meier method, log-rank statistics and multivariable Cox regression.

Results The univariate analysis demonstrated that significant prognostic factors were T stage (p=0.000), N status (p=0.000), Her2 status (negative or Her2-low) (p=0.006) and TILs (p=0.002). The 5 year OS of patients with high TILs was significantly higher than those with low TILs (94.6% vs. 67.7%, P=0.002). Cox regression multivariate analysis showed that independent predictors of OS were TILs (p=0.03; HR=0.25; 95%CI 0.07–0.89) and CD8+ iTILs (p=0.04; HR=0.20 95%CI 0.04–0.93). There was also a correlation between TILs and Her2 status (P=0.02) where low TILs were associated with Her2-low status, infiltration of CD8+ sTILs and T stage (p=0.04).

Conclusion/Implications High TILs and CD8+ iTILs were associated with better prognosis in early-stage TNBC patients. We recommend their inclusion in routine pathological reports. Further research is needed to explore the potential of TILs as predictive markers for immunotherapy in TNBC.

Abstract EP025/#623 Table 1

Correlation between TILs, CD8+ iTILs, CD8+ sTILs and clinicopathological features (n = 105)

Abstract EP025/#623 Figure 1

Kaplan-Meier curves for OS according to TILs categories defined by median TIL value as the cut-off

Abstract EP025/#623 Figure 2

Kaplan-Meier curves for OS according to CD8+ iTlLs categories defined by median iTlLs value as the cut-off

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