Introduction To compare the survival outcomes of radical hysterectomy (RH) with extended pelvic lymphadenectomy (EL) versus conventional pelvic lymphadenectomy (CL) in cervical cancer patients with stage IB to IIA.To compare the survival outcomes of radical hysterectomy (RH) with extended pelvic lymphadenectomy (EL) versus conventional pelvic lymphadenectomy (CL) in cervical cancer patients with stage IB to IIA.

Description We retrospectively evaluated 405 patients who underwent laparoscopic or robot RH with CL or EL for cervical cancer (stage IB-IIA) between 1995 and April 2019. We performed propensity score matching analysis to control for selection bias. We matched 111 patients for each group and compared their long-term clinical and survival outcomes using Cox regression analysis. The median follow-up period was 59 months. The EL group had better survival outcomes than the CL group, with higher rates of OS (95.5% vs. 87.4%, p = 0.013) and DFS (82.9% vs. 75.7%, p = 0.030). The EL group also had lower risks of death (HR = 0.305, 95% CI: 0.112–0.827, p = 0.028) and recurrence (HR = 0.495, 95% CI: 0.259–0.094, p = 0.034).

Conclusion/Implications The study is a retrospective analysis of a large sample size (405 patients), which increases the statistical power of the results. RH with EL improved the survival outcomes of cervical cancer patients with stage IB to IIA compared to RH with CL. RH with EL improved the survival outcomes of cervical cancer patients with stage IB to IIA compared to RH with CL