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EP419/#629  Prognostic analysis of FIGO stage I and II of vulvar cancer: a retrospective study of 123 cases
  1. Ines Zemni1,
  2. Houyem Mansouri2,
  3. Mohamed Ali Ayadi1,
  4. Amani Jellali1,
  5. Riadh Chargui1 and
  6. Tarek Ben Dhiab1
  1. 1Salah Azaiz Institute, Faculty of Medicine of Tunis, University of Tunis El Manar, Department of Surgical Oncology, Tunis, Tunisia
  2. 2Regional Hospital of Jendouba, University of Tunis ELManar, Department of Surgical Oncology, Jendouba, Tunisia


Introduction To identify clinical, pathological features and survival predictors of vulvar cancer in patients with no lymph node metastasis.

Methods A retrospective study of 123 patients who were diagnosed and treated for vulvar cancer staged I and II at the Salah Azaiez Institute of Oncology between 1994 and 2022

Results Mean age was 65.61±14.081 years (range, 30–104 years) and median follow-up was 37.84±40.221 months. Surgery was a radical vulvectomy,hemivulvectoy, and pelvic exenteration in respectively 96.7%, 2.4%, and 0.8% of cases. Inguinal Sentinel lymph node (LN) biopsy was performed in 10 cases (8.1%), bilateral inguinofemoral lymphadenectomy (ILND) in 101 cases (81.1%), and unilateral (ILND) in 14 cases (11.4%). The mean tumor size was 38.04±20.45 mm. Tumors were classified as stage pT1a, pT1b, pT2, and pT3 in respectively 4.9%, 81.3%,13%%, and 0.8% of cases. The 5 years overall survival was 64.2% and decreased with advanced age ≥ 70 years (45% vs 74% in patients younger than 70 years, p= 0.014) and with the presence of perineural invasion (PNI) (0% vs 70.7%, p=0.028). The 5-year recurrence-free survival was 65.8% and decreased with a number of retrieved LN less than 12 (0% vs 45.3% in case of 12 or more LN;p=0.001), and the presence of PNI (33.3% vs 71.4%, p=0.002). Moreover, the rate of recurrence increased with the pT stage (0%, 26%, and 52% respectively in stages pT1a, pT1b, and pT2–3;p=0.021).

Conclusion/Implications The survival of patients with stage I and II of vulvar cancer is correlated to the number of retrieved LN and the presence of PNI.

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