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EP385/#290  A comparative study of self-collected versus clinician-collected specimens in detecting high-risk HPV infection: a prospective cross-sectional study
  1. Charuwan Tantipalakorn,
  2. Natnipa Parapob,
  3. Suree Lekawanvijit,
  4. Jatupol Srisomboon and
  5. Kittipat Charoenkwan
  1. Chiang Mai University, Obstetrics and Gynecology, Muang, Thailand


Introduction The primary endpoint of this study aimed to investigate the correlation between self-collected vaginal specimens versus clinician-collected cervical specimens in detecting high-risk HPV infection. Furthermore, the secondary endpoint was the satisfaction of self-collection for HPV testing.

Methods From October 2021 to September 2022, 104 women with HPV16 or HPV18-positive or other 12 high-risk HPV-positive with cytology ≥ ASCUS were enrolled. The primary endpoint of the study was the assessment of the level of agreement and correlation between human papillomavirus (HPV) testing results obtained from self-collected vaginal specimens and those obtained from clinician-collected cervical specimens in detecting high-risk HPV infections, which was accomplished using Cohen’s Kappa coefficient (k). The secondary endpoint was the satisfaction of women with the vaginal self-collected method. Data analysis was using STATA (StataCorp LLC, College Station, TX), with results considered statistically significant at a P-value of less than 0.05.

Results Paired self-collected and clinician-collected specimens were obtained from 104 women with previous HPV-positive results. The agreement in detecting HPV infection was ‘substantial’ with a kappa coefficient of 0.75. More than 90% of participants rated self-collection as a very good to excellent method because of convenience and safety. For methods of further follow-up, 51% of participants chose self-sampling, the remaining preferred collection by clinicians. There were no complications with the intervention observed.

Conclusion/Implications Self-collected HPV testing is substantially correlated with clinician-collected specimens in detecting cervical high - risk HPV infection. This cell collection method appears to be highly satisfactory and may provide better compliance in the detection of cervical HPV infection.

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