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EP377/#1514  First implementation of HPV self-sampling in vietnam: an assessment of accuracy and feasibility
  1. Ngoc Phan1,
  2. Dung Nguyen1,
  3. Hoa Nguyen2,
  4. Anh Le3,
  5. Han Truong3,
  6. Quy Tran1,
  7. Li Min Lim4 and
  8. Linda Van Le5
  1. 1Da Nang Oncology Hospital, Department of Gynecology, Da Nang, Viet Nam
  2. 2Shiga University of Medical Science, Medical Oncology, Otsu, Japan
  3. 3Da Nang Oncology Hospital, Pathology, Da Nang, Viet Nam
  4. 4National University Cancer Institute, Gynecologic Oncology, Singapore, Singapore
  5. 5University of North Carolina at Chapel Hill, Gynecologic Oncology, Chapel Hill, USA


Introduction WHO recommends HPV self-sampling as a safe and highly accepted additional strategy in cervical cancer screening for women aged 30–60 years [1]. Currently, no research on HPV self-sampling has been conducted in Vietnam. This study aims to evaluate the accuracy, acceptability, and women’s experience of HPV self-sampling compared to healthcare provider collection at Da Nang Oncology Hospital.

Methods A cross-sectional study was conducted at Da Nang Oncology Hospital from April to June 2023 for women aged 30–65 years. HPV self-sampling was performed using Copan Self Vaginal FLOQSwabs prior to physician-collected HPV on the same day. Samples were preserved in Thinprep PreservCyt and analysed by Roche Cobas 4800.

Results The study included 108 cases, for which the sample-inadequacy rate was 4.6% (5/108 cases). Patient’s mean age was 44.0 ± 8.1 with 75.0% aged 30–49 years. Among 103 qualified cases, positive rates for HPV16, HPV18 and 12 other high-risk HPV types were 0.97%, 0% and 2.91% respectively in self-collected versus 0.97%, 0.97% and 2.91% in physician-collected samples. The accuracy of HPV self-sampling was 99.0% when using physician-sampling as a reference (102/103 cases). 50.0% of women preferred self-collection, 44.4% preferred physician-collection, and 5.6% had no preference. 77.8% believed healthcare provider-sampling was more accurate than self-sampling. Only 8.3% reported painful experience and 9.3% encounted difficulty with self-sampling. The majority (91.7%) would choose HPV self-sampling at home for next screening and 96.3% would recommend it to other women.

Conclusion/Implications HPV self-sampling is an accurate and highly acceptable approach for Vietnamese women to improve the cervical cancer screening rate.

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