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EP372/#735  Human papillomavirus infections among women with cervical lesions in Uzbekistan
  1. Nargiza Zakhirova1,
  2. Mirzagaleb Tillyashykhov2,
  3. Sayde Djanklich3,
  4. Viloyat Saidakhmedova3,
  5. Muzafar Otajanov3 and
  6. Elnora Osmanova3
  1. 1Tashkent Pediatric Medical Institute, Oncological, Tashkent, Uzbekistan
  2. 2Republican Specialized Scientific-Practical Medical Center of Oncology and Radiology, Onco-urology, Tashkent, Uzbekistan
  3. 3Republican Specialized Scientific-Practical Medical Center of Oncology and Radiology, Gynecologic, Tashkent, Uzbekistan


Introduction The prevalence of HPV types 16 and 18 was studied in healthy women, patients with concomitant and precancerous diseases of the cervix and cervical cancer women from Tashkent city.

Methods Totally 787 (100%) women were examined, and 79 (10%) of them were with cervical lesions and 21 (2.7%) - healthy. Out of the patients with cervical lesions, morphologically eroded ectropion, endocervicosis, polyps were registered in 26 (32.9%) women, CIN - 19 (24%) patients and cervical cancer - 24 (30.4%). The age of women ranged from 18 to 62 years. The material for the study was smears and biopsies from the cervix. HPV DNA detection with Genotyping was performed by PCR.

Results In 26.9% of women with concomitant cervical lesions, there was revealed HPV types 16 and 18. Out of CIN patients it was detected HPV DNA in 73.7% cases; out of cervical cancer patients - HPV was detected in 95.6% cases. Moreover, out of healthy women, without visual pathology of the cervix, HPV was detected in 19%. It was performed cervical conization by an electrosurgical method with systemic antiviral therapy for patients with concomitant diseases and CIN. Patients were monitored every 6 months by using HPV test of cervical smears. After treatment HPV DNA was present in 49.9% of smear samples.

Conclusion/Implications HPV has the ability to eliminate from the human body on its own, however, the results of the study showed that even after local and systemic therapy, HPV can persist in the body, finally lead to invasive cervical cancer.

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