Introduction A state level national screening program was designed and decided to implement through a pilot in the Bukhara region, in age group of women from 45–65 years (incidence rate about 80 per 100 000 population).

Methods Bukhara region has 13 subdivisions. Every subdivision was equipped with a digital mammograph (13 fixed and 2 mobile units) with centralized real-time system of registration and reporting using specialized software (Uzfujirunlek). All mammograms were sent to central reading center based at National Cancer Center in Tashkent in real time. Standard BIRADS scoring is used. Here we report data from the beginning of screening program (May 2021) to January 2023.

Results A total of 137 245 women were screened. Out of this group 398 (0.3%) were found to have BIRADs 5, 4 998 women (3.6%) were found to have BIRADs 4 and BIRADS 1–2 category was reported in 126 859 women (92.4%). All patients with BIRADs 0–4-5 (10 903) results were sent for the further examination. Breast cancer were detected in 377 (3.5% from BIRADs 0–4-5) women. 81 cases were diagnosed in stage I (22.4%), 214 in stage II (58.5%), 42 in stage III (8.5%) and 40 in stage IV (10.6%). The highest number of patients were between the age of 55–65 (51.4%), and 48.6% were in age 45–55.

Conclusion/Implications Screening at the population level in Uzbekistan proved to be feasible. Almost 80% of women were diagnosed at the early stages. It becomes possible to decrease mortality and increase survival rate of breast cancer patients in Uzbekistan.