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EP360/#693  Prognostic factors for survival in patients with rare peritoneal surface malignancy: diffuse malignant peritoneal mesothelioma- a single institution experience
  1. Jimin Lee1,
  2. Jeeyeon Kim2,
  3. Joo-Hyuk Son3,
  4. Tae-Wook Kong2 and
  5. Suk-Joon Chang2
  1. 1Ajou University School of Medicine, Obgy, Suwon city, Korea, Republic of
  2. 2Ajou University Medical Center, Obstetrics and Gynecology, Suwon, Korea, Republic of
  3. 3Ajou University School of Medicine, Obstetrics and Gynecology, Suwon, Korea, Republic of


Introduction Diffuse malignant peritoneal mesothelioma (DMPM) is a rare and aggressive cancer that originates in the peritoneum. Due to its poor prognosis, a better understanding of its clinical characteristics and prognostic factors is needed. This study aimed to investigate such factors and their association with survival in patients with DMPM.

Methods We conducted a retrospective analysis of patients diagnosed with DMPM at Ajou University Hospital from February 2000 to June 2022. Various clinical characteristics and potential risk factors that may influence survival were evaluated.

Results We identified a total of 22 patients (6 male, 16 female) with DMPM. The median age of the patients was 57.5 years (range 20–80). The overall median survival was 31.1 months (95% CI 15.8–46.4), with a 5-year survival rate of 25.3%. Of the patients, 2 received cytoreductive surgery and followed by adjuvant chemotherapy, 4 received cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (CRS+HIPEC). Survival analysis revealed that cytoreductive surgery (p=0.014) and intraperitoneal chemotherapy (p=0.008) were significantly associated with overall survival.

Conclusion/Implications Our findings suggest that cytoreductive surgery and intraperitoneal chemotherapy are important treatment options for improving survival in patients with DMPM. Further research is needed to better understand the optimal treatment approach for this rare and aggressive cancer.

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