Introduction The detection of high grade cervical intraepithelial neoplasia is traditionally done by conventional colposcopy. However, this procedure requires special equipment and needs to be performed by a specialist. Data on the performance of mobile colposcopy are still limited, so we aimed to evaluate the performance of mobile colposcopy in detecting high grade cervical intraepithelial neoplasia comparing with conventional colposcopy.

Methods Patients with abnormal cervical cancer screening tests were included in the study. Mobile colposcopy and conventional colposcopy were performed in all patients then biopsy was done following the standard recommendation. Images from mobile colposcopy were assessed by two independent doctors. The diagnostic performance was evaluated and the colposcopic results were compared between mobile colposcopy and conventional colposcopy.

Results Ninety-one patients were enrolled in the study. There were poor-quality mobile colposcopic images in 3 patients. The accuracy in detecting high grade cervical intraepithelial neoplasia were 76.14% using mobile colposcopy, and 79.12% using conventional colposcopy. The sensitivity, specificity, positive predictive value, and negative predictive value were 52.94%, 81.82%, 40.91%, and 87.88% in mobile colposcopy, and 61.11%, 83.56%, 47.83%, and 89.71% in conventional colposcopy, respectively. The concordance rate between mobile colposcopy and conventional colposcopy was 72.73%. There was a fair agreement between mobile colposcopy and conventional colposcopy (Kappa = 0.273, 95%CI 0.048–0.497).

Conclusion/Implications The diagnostic performance of mobile colposcopy was comparable to conventional colposcopy with a fair agreement between the two procedures. Mobile colposcopy may be an alternative option in the diagnosis of high grade cervical intraepithelial neoplasia.