Introduction Although there have been advancements in triaging women with pelvic masses using multimodal laboratory assays like ROMA and CPH-I, there is still a need for more cost-effective and efficient models. Additionally, there is a need for a reliable model that can detect EOC in premenopausal women at an early stage.

Methods The study analyzed data from 122 EOC patients and 820 patients with BOMs. Pearson’s correlation coefficient, the Mann-Whitney U test, the area under the curve (AUC) were used for analysis.

Results 39.3% of the 122 EOC patients had stage I-II cancer, and 60.7% had stage III-IV cancer. Multivariate logistic regression analysis revealed that human epididymal secretory protein 4 (HE4) and red cell distribution width (RDW) were significant predictors of EOC and constituted the full model (FM). The AUCs of FM for predicting EOC were comparable to those of ROMA or CPH-I, regardless of tumor stage or menopausal status. However, the sensitivity of FM at a set specificity of 75% was significantly higher than that of ROMA in predicting EOC in premenopausal women.

Conclusion/Implications The AUCs of FM were comparable to those of ROMA or CPH-I in terms of predicting EOC, regardless of the tumor stage or menopausal status; however, the FM was more sensitive than ROMA in predicting EOC in premenopausal women at a set specificity of 75%. Additionally, FM has the advantage of being less expensive than ROMA or CPH-I. Further prospective studies are required to validate these results of present study.