Introduction To examine the impact of PDS versus IDS on hemodynamic and transfusion characteristics as well as the length of care in the intensive care unit (ICU).

Methods All consecutive pts with EOC (FIGO stage ≥IIIC) undergoing PDS or IDS between 01/2018 and 12/2019 were included in the analysis. All data were collected in a prospectively maintained database and retrospectively analyzed regarding anaesthesiological characteristics.

Results 270 pts could be included, 181 pts (67%) were treated with PDS, 89 pts (33%) underwent IDS. IDS pts showed a higher rate of thromboembolic events in history (10.1%) vs. PDS pts (1.1%, p<0.001), further differences in comorbidities or medications were not found. Table 1 shows patient and tumor characteristics. The initial median hemoglobin value in IDS pts was 10.5 g/dl (9.3;11.5) vs. PDS pts 11.7 g/dl (10.8;12.7, p<0.001) and IDS pts were more frequently transfused intraoperatively (PDS 21.5% vs. IDS 42.7%, p<0.001). PDS pts had higher fluid demands of crystalloid [4500 ml (3500;5000) vs. 4000 ml (3000;4500), p=0.015] and colloid infusions [2000 ml (1500;2000) vs. 1500 ml (1000;2000), p=0.003], whereas other hemodynamic characteristics like highest heart rate, lowest arterial pressure, norepinephrine requirements, highest lactate level, or the amount of urine output were comparable. Table 2 demonstrates further anesthesiological and surgical parameters.

Conclusion/Implications In comparison to PDS the IDS showed intraoperatively lower fluid but higher transfusion demands and was not associated to a reduced stay in ICU. The hemodynamic characteristics did not show any benefits neither. These data indicate that IDS is similarly associated to a high impact on the anaesthesiological and ICU management.